A rare case of generalized tonic‐clonic seizure related to paclitaxel infusion. (18th August 2019)

• Record Type: Journal Article
• Authors: Ajiboye, Oyintayo; Renu, Nair; Ezegwu, Olisa; Vohra, Ishaan; Ayub, Muhammed Talha
• Is Part Of: Journal of clinical pharmacy and therapeutics. Volume 44:Number 6(2019)
• Page Start: 974
• Page End: 976
• Publication Date: 2019-08-18
• Subjects: chemotherapy -- cremophor EL -- hypersensitivity reaction -- paclitaxel -- seizures; Clinical pharmacology -- Periodicals; Chemotherapy -- Periodicals; 615
• DOI: 10.1111/jcpt.13027
• Languages: English
• ISSNs: 0269-4727

Abstract

Abstract: What is known and objective: Paclitaxel (Taxol) is an antineoplastic agent approved in the United States for the treatment of lung, breast, cervical, pancreatic cancers and Kaposi sarcoma. Paclitaxel does not cross the blood brain barrier, so central nervous system adverse effects are uncommon. Case description: We describe a 60‐year‐old woman with Stage IIIa squamous cell carcinoma of the left lung, who developed a generalized tonic‐clonic seizure during her first infusion of paclitaxel. What is new and conclusion: Seizure related to a hypersensitivity reaction from paclitaxel infusion are rare but could be life‐threatening and require immediate recognition, treatment and exclusion of other possible aetiologies.