Cholinergic signalling mechanisms and early implant healing phases in healthy versus generalized aggressive periodontitis patients: A prospective, case–control study. (9th September 2019)

• Record Type: Journal Article
• Authors: Meriç, Pınar; Buduneli, Nurcan; Kanmaz, Burcu; Gürlek, Önder; Çömlekoğlu, Erhan; Calvert, Gareth; Lappin, David F.; Nile, Christopher
• Is Part Of: Journal of clinical periodontology. Volume 46:Number 11(2019)
• Page Start: 1155
• Page End: 1163
• Publication Date: 2019-09-09
• Subjects: acetylcholine -- esterases -- implants -- periodontitis -- SLURP‐1; Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.13185
• Languages: English
• ISSNs: 0303-6979

Abstract

Abstract: Aims: Periodontal diseases negatively affect implant osseointegration. Perturbations in non‐neuronal cholinergic signalling mechanisms are associated with periodontitis; however, their role in generalized aggressive periodontitis (GAgP) is unknown. The aim of this prospective case–control study was to determine the relationship between non‐neuronal cholinergic signalling mechanisms, secreted Ly‐6/uPAR‐related protein‐1 (SLURP‐1), interleukin‐17 (IL‐17) family cytokines and healing of dental implants in health and GAgP. Material and Methods: Thirteen GAgP patients and seven periodontally healthy individuals (PH) were recruited. Peri‐implant crevicular fluid (PICF) was obtained at baseline and 1 month post‐placement. Acetylcholine (ACh) levels and cholinesterase activity were determined biochemically. SLURP‐1, IL‐17A and IL‐17E levels were determined by ELISA. Marginal bone loss (MBL) at 1 and 6 months post‐placement was determined radiographically. Results: The concentration of ACh, cholinesterase activity and IL‐17A levels was elevated in PICF of patients with GAgP compared to PH individuals at baseline and 1 month post‐placement. The concentration of ACh and cholinesterase activity levels in PICF correlated with levels of IL‐17A and MBL around implants 1 month post‐placement in patients with GAgP. Conclusions: Non‐neuronal cholinergic mechanisms may play a role in the aetiopathogenesis of GAgP and may directly or indirectly, through modulation of IL‐17A, influence early implant osseointegration and potential long‐term implant survival.