A Chemical Photo‐Oxidation of 5‐Methyl Cytidines. Issue 20 (22nd August 2019)

• Record Type: Journal Article
• Authors: Jin, Xiao‐Yang; Wang, Rui‐Li; Xie, Li‐Jun; Kong, De‐Long; Liu, Li; Cheng, Liang
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 20(2019)
• Page Start: 4685
• Page End: 4690
• Publication Date: 2019-08-22
• Subjects: 5-methylcytidine -- 5-formylcytidine -- photochemical oxidation -- artificial enzymes -- epigenetic modifications; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201900811
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A new approach for the oxidation of 5‐methyl cytidine modification in nucleic acids to 5‐formyl cytidine is reported. This method displays excellent chemo‐/bio‐ selectivity, from which the methyl group in cytidine nucleosides could be selectively oxidized to biologically important formyl functionality without interfering with other cellular biomolecules. Abstract :