Enantioselective Syntheses of α‐exo‐Methylene‐Lactones via Organocatalytic Halolactonization. Issue 20 (3rd September 2019)

• Record Type: Journal Article
• Authors: Wang, Wei; He, Haoquan; Gan, Min; Wang, Haitao; Wang, Yuqiang; Jiang, Xiaojian
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 20(2019)
• Page Start: 4797
• Page End: 4804
• Publication Date: 2019-09-03
• Subjects: Halolactonization -- Organocatalyst -- Enantioselectivity -- α-exo-Methylene-γ-butyrolactones -- α-exo-Methylene-δ-valerolactones; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201900728
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: α‐ exo ‐Methylene‐γ‐butyrolactones and α‐ exo ‐methylene‐δ‐valerolactones constitute an important group of natural and bioactive products. An enantioselective halolactonization of dienoic acids using (DHQD)2 PHAL catalyst is described. Various halogenated α‐ exo ‐methylene‐γ‐butyrolactones and α‐ exo ‐methylene‐δ‐valerolactones were obtained in high yields and enantioselectivities. The resulting enantioenriched halogenated α‐ exo ‐methylene‐lactones were found to exhibit significant tumor‐inhibiting activities. Abstract :