New perspectives on screening and early detection of endometrial cancer. Issue 12 (28th June 2019)

• Record Type: Journal Article
• Authors: Costas, Laura; Frias‐Gomez, Jon; Guardiola, Magdalena; Benavente, Yolanda; Pineda, Marta; Pavón, Miquel Á.; Martínez, José M.; Climent, Maite; Barahona, Marc; Canet, Júlia; Paytubi, Sonia; Salinas, Mónica; Palomero, Luis; Bianchi, Ilaria; Reventós, Jaume; Capellà, Gabriel; Diaz, Mireia; Vidal, August; Piulats, Josep M.; Aytés, Álvaro; Ponce, Jordi; Brunet, Joan; Bosch, Francesc X.; Matias‐Guiu, Xavier; Alemany, Laia; de Sanjosé, Silvia
• Is Part Of: International journal of cancer. Volume 145:Issue 12(2019)
• Page Start: 3194
• Page End: 3206
• Publication Date: 2019-06-28
• Subjects: endometrial cancer -- early detection -- screening -- pap smears -- genomics -- biomarkers; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.32514
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : Due to the anatomical continuity of the uterine cavity with the cervix, genomic exploitation of material from routine Pap smears and other noninvasive sampling methods represent a unique opportunity to detect signs of disease using biological material shed from the upper genital tract. Recent research findings offer a promising perspective in the detection of endometrial cancer, but certain questions need to be addressed in order to accelerate the implementation of novel technologies in a routine screening or clinical setting. We discuss here new perspectives on detection of endometrial cancer using genomic and other biomarkers in minimally invasive sampling methods with a special focus on public health classic screening criteria, highlighting current gaps in knowledge.