Biomarkers of oral inflammation in perinatally HIV‐infected and perinatally HIV‐exposed, uninfected youth. (5th September 2019)

• Record Type: Journal Article
• Authors: Moscicki, Anna‐Barbara; Yao, Tzy‐Jyun; Russell, Jonathan S.; Farhat, Sepideh; Scott, Mark; Magpantay, Larry; Halec, Gordana; Shiboski, Caroline H.; Ryder, Mark I.
• Other Names: Yang Ester investigator.; Shearer William investigator.; Paul Mary investigator.; Cooper Norma investigator.; Harris Lynette investigator.; Kemp‐Posterman Karen investigator.; Wun Selene investigator.; Purswani Murli investigator.; Baig Mahboobullah investigator.; Cintron Anna investigator.; Zeni Jennifer investigator.; Puga Ana investigator.; Navarro Sandra investigator.; Patton Doyle investigator.; Leon Deyana investigator.; Ng Man Wai investigator.; Burchett Sandra investigator.; Karthas Nancy investigator.; Kammerer Betsy investigator.; Jurado Ray investigator.; Kuttab Johnny investigator.; Vorachek Ashlee investigator.; Yogev Ram investigator.; Sanders Margaret Ann investigator.; Malee Kathleen investigator.; Hunter Scott investigator.; Badner Victor investigator.; Garreett Ronald investigator.; Wiznia Andrew investigator.; Burey Marlene investigator.; Nozyce Molly investigator.; Chialastri Susan investigator.; Chen Janet investigator.; Ivey Latreca investigator.; Bulkley Maria Garcia investigator.; Grant Mitzie investigator.; Gonzalez Ramon investigator.; Acevedo‐Flores Midnela investigator.; Rios Heida investigator.; Olivera Vivian investigator.; Townsend Janice investigator.; Silio Margarita investigator.; Jones Medea investigator.; Sirois Patricia investigator.; Gandhi Roopa investigator.; McFarland Elizabeth investigator.; Barr Emily investigator.; McEvoy Robin investigator.; Markowitz Kenneth investigator.; Dieudonne Arry investigator.; Bettica Linda investigator.; Adubato Susan investigator.;
• Is Part Of: Journal of clinical periodontology. Volume 46:Number 11(2019)
• Page Start: 1072
• Page End: 1082
• Publication Date: 2019-09-05
• Subjects: cytokines -- oral health -- perinatal HIV‐infected youth -- periodontal inflammation; Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.13179
• Languages: English
• ISSNs: 0303-6979

Abstract

Abstract: Aim: To examine oral biomarkers that have been associated with periodontal disease progression in HIV‐infected adults in perinatally HIV‐infected and HIV‐exposed but uninfected youth. Material and Methods: This was a cross‐sectional, multicentre substudy of youth participating in the Oral Health Pediatric HIV/AIDS Cohort study. Gingival crevicular fluid repository samples from participants with and without periodontal disease (using Gingival Index [GI] and Bleeding on Probing [BOP] parameters on dental examination) were tested for concentration levels of inflammatory biomarkers. Associations were assessed using Wilcoxon test and Spearman correlation. Results: For perinatal HIV youth ( n = 129), the markers consistently elevated ( p < .05) in sites with GI ≥2 and in sites with BOP were interleukin‐1β, 6 and 13, macrophage inflammatory protein‐1α and metalloproteinase‐9. Serum tumour necrosis factor‐α and soluble CD14 were positively correlated with a summary count of elevated cytokines. No associations were seen among HIV‐uninfected subjects ( n = 71). Conclusions: The association of oral biomarkers of inflammation with clinical indicators of periodontal inflammation and systemic immune activation suggests that perinatal HIV‐infected youth may be at higher risk for developing significant periodontal disease, associated with tooth loss and HIV progression. More frequent dental care of this group is needed to prevent potential periodontal progression.