Clinical Significance of Tumor-Infiltrating T Cells and Programed Death Ligand-1 in Patients with Pancreatic Cancer. (21st October 2019)

• Record Type: Journal Article
• Authors: Yoshida, Sayumi; Ito, Zensho; Suka, Machi; Bito, Tsuuse; Kan, Shin; Akasu, Takafumi; Saruta, Masayuki; Okamoto, Masato; Kitamura, Hiroaki; Fujioka, Shuichi; Misawa, Takeyuki; Akiba, Tadashi; Yanagisawa, Hiroyuki; Sugiyama, Haruo; Koido, Shigeo
• Is Part Of: Cancer investigation. Volume 37:Number 9(2019)
• Page Start: 463
• Page End: 477
• Publication Date: 2019-10-21
• Subjects: TIL -- PD-L1 -- pancreatic cancer -- prognosis; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2019.1661427
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: The associations of the immunological status of the pancreatic ductal adenocarcinoma (PDA) microenvironment with prognosis were assessed. A high tumor-infiltrating lymphocyte (TIL) density was associated with a better prognosis. Importantly, even with a high density of TILs, the PDA cells with programed cell death-ligand 1 (PD-L1) expression showed a worse prognosis than the patients with negative PD-L1 expression. A significant association between a better prognosis and a tumor microenvironment with a high TIL density/negative PD-L1 expression was observed. Assessments of a combined immunological status in the tumor microenvironment may predict the prognosis of PDA patients following surgical resection.