Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a. (21st October 2019)

• Record Type: Journal Article
• Authors: Tahara, Tomomitsu; Tahara, Sayumi; Horiguchi, Noriyuki; Kawamura, Tomohiko; Okubo, Masaaki; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Shibata, Tomoyuki; Urano, Makoto; Tsukamoto, Tetsuya; Kuroda, Makoto; Ohmiya, Naoki
• Is Part Of: Cancer investigation. Volume 37:Number 9(2019)
• Page Start: 417
• Page End: 426
• Publication Date: 2019-10-21
• Subjects: Narrow-band imaging -- gastric mucosa -- Helicobacter pylori eradication -- downregulation of miR-124a; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2019.1663207
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori ( H. pylori ) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.