Stress hormones and eating disorders. (1st November 2019)

• Record Type: Journal Article
• Authors: Chami, Rayane; Monteleone, Alessio Maria; Treasure, Janet; Monteleone, Palmiero
• Is Part Of: Molecular and cellular endocrinology. Volume 497(2019)
• Publication Date: 2019-11-01
• Subjects: Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2018.12.009
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Aims: The aim of this paper is to emphasize the role of stress processes in the aetiology of eating disorders. Methods: We have examined the literature for evidence that people with eating disorders might exhibit markers of stress and show signs of the "maltreated ecophenotype". Results: Early adversity is more common among people with binge eating behaviours. The secondary effects of malnutrition, which are mostly marked in anorexia nervosa, may be an added stressor that could also contribute to the stress related phenotype. People with eating disorders have anomalies in brain structure, reward and punishment sensitivity, and the balance between HPA and SMA function. These may be potential targets for treatment. Highlights: There are markers of the maltreated ecophenotype among people with EDs. Epigenetic mechanisms may mediate the impact of stress on ED development. Childhood trauma may impact the integrity of some brain structures in EDs. Adverse life events may increase sensitivity to punishment and rejection in EDs. Malnutrition should be accounted for when exploring HPA activity in EDs.