Dicitrinones E and F, citrinin dimers from the marine derived fungus Penicillium citrinum HDN-152-088. Issue 44 (31st October 2019)

• Record Type: Journal Article
• Authors: Wang, Lu; Li, Changlong; Yu, Guihong; Sun, Zichao; Zhang, Guojian; Gu, Qianqun; Zhu, Tianjiao; Che, Qian; Guan, Huashi; Li, Dehai
• Is Part Of: Tetrahedron letters. Volume 60:Issue 44(2019)
• Publication Date: 2019-10-31
• Subjects: Marine fungus -- Penicillium citrinum -- Citrinin dimers -- Antioxidant activity; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151182
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Two new two new citrinin dimers with rare C-7/C-7′ carbon-bridges were isolated from a marine derived fungus. Compound 2 was the first citrinin dimer consisted of two mono-benzene monomers. Compound 1 displayed antioxidant activity. Abstract: Two new citrinin dimers named dicitrinones E and F (1 and2 ), together with one biogenetically related known citrinin monomer (3 ), were isolated from the marine derived fungus Penicillium citrinum HDN-152-088. All structures including the absolute configurations were elucidated on the basis of comprehensive spectroscopic data, and assisted by ECD calculations. Among them, compounds1 and2 belong to the class of citrinin dimers with a rare carbon-bridged C-7/C-7′ linkage. Compound1 displayed antioxidant activity with IC50 value of 23.73 μM.