Liver phantom design and dosimetric verification in participating institutions for a proton beam therapy in patients with resectable hepatocellular carcinoma: Japan Clinical Oncology Group trial (JCOG1315C). (November 2019)

• Record Type: Journal Article
• Authors: Nishio, Teiji; Tachibana, Hidenobu; Kase, Yuki; Hotta, Kenji; Nakamura, Mitsuhiro; Tamura, Masaya; Terunuma, Toshiyuki; Toshito, Toshiyuki; Yamashita, Haruo; Ishikura, Satoshi; Fuji, Hiroshi; Akimoto, Tetsuo; Nishimura, Yasumasa
• Is Part Of: Radiotherapy and oncology. Volume 140(2019)
• Page Start: 98
• Page End: 104
• Publication Date: 2019-11
• Subjects: Dosimetric verification -- Water tank-type liver phantom -- Liver proton therapy clinical trial; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2019.06.005
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: The water tank-type liver phantom for proton therapy in the JCOG trial was designed. This audit targeted the proton therapy system of three vendors at five institutions. The difference between calculated and measured dose was within 3% for all systems. Abstract: Background and purpose: In Japan, the first domestic clinical trial of proton beam therapy for the liver was initiated as the Japan Clinical Oncology Group trial (JCOG1315C: Non-randomized controlled study comparing proton beam therapy and hepatectomy for resectable hepatocellular carcinoma). Purposes of this study were to develop a new dosimetric verification system and to carry out a credentialing for the JCOG1315C clinical trial. Materials and methods: Accuracy and differences in doses in proton treatment planning among participating institutions were surveyed and investigated. We designed and developed a suitable water tank-type liver phantom for a dosimetric verification of proton beam therapy for liver. In a visiting survey of five institutions participating in the clinical trial, we performed the dosimetric verification using the liver phantom and an air-filled ionization chamber. Results: The shape of the dose distributions calculated in proton treatment planning was characteristic and dependent on the manufacturers of the proton beam therapy system, the proton treatment planning system and the setup at the participating institutions. Widths of the lateral penumbra were 5.8–12.7 mm among participating institutions. The accuracy between the calculated and the measured doses in the proton irradiation was within 3% at five measurement points including both points on the isocenter and off the isocenter. Conclusions: These findings confirmed the accuracy of the delivery doses in the institutions participating in the clinical trial, and the clinical trial with integration of all institutions (five institutions) could be initiated.