Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities. Issue 22 (15th November 2019)

• Record Type: Journal Article
• Authors: Antipova, Tatiana V.; Zaitsev, Kirill V.; Oprunenko, Yuri F.; Ya. Zherebker, Alexander; Rystsov, Gleb K.; Zemskova, Marina Y.; Zhelifonova, Valentina P.; Ivanushkina, Natalya E.; Kozlovsky, Anatoly G.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 29:Issue 22(2019)
• Publication Date: 2019-11-15
• Subjects: Austalide -- Fungus -- Aspergillus ustus -- Prostate and bladder cancer cells -- AKT-mTORC1 signaling pathway; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2019.126708
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: New austalides V and W were isolated from the fungus Aspergillus ustus VKM F-4692. These compounds have new 5/6/6/6/6/5/5 heptacyclic ring system. Austalides V and W inhibit proliferation and migration of cancer cells. Austalide W suppresses activity of key signaling pathways regulating cancer cell growth. Abstract: Two new austalide meroterpenoids, named austalides V and W (1 and2 ), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G ), a structural fragment, first found in austalides. Austalides V (1 ) and W (2 ) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.