Dyslipidemia in retinal metabolic disorders. Issue 10 (5th September 2019)

• Record Type: Journal Article
• Authors: Fu, Zhongjie; Chen, Chuck T; Cagnone, Gael; Heckel, Emilie; Sun, Ye; Cakir, Bertan; Tomita, Yohei; Huang, Shuo; Li, Qian; Britton, William; Cho, Steve S; Kern, Timothy S; Hellström, Ann; Joyal, Jean‐Sébastien; Smith, Lois EH
• Is Part Of: EMBO molecular medicine. Volume 11:Issue 10(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-09-05
• Subjects: dyslipidemia -- FGF21 -- photoreceptor -- retinal metabolism -- β‐oxidation; Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.201910473
• Languages: English
• ISSNs: 1757-4676

Abstract

Abstract: The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid‐rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders. Abstract : In the growing field of lipid metabolism in retinopathies, this review provides insights on the possible implication of lipid metabolism, energy demands and fuel source in the retina, but also systemic dyslipidemia on neovascular retinopathy.