Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019). Issue 20 (16th October 2019)

• Record Type: Journal Article
• Authors: Wang, Qixue; Liu, Xing; Zhou, Junhu; Yang, Chao; Wang, Guangxiu; Tan, Yanli; Wu, Ye; Zhang, Sijing; Yi, Kaikai; Kang, Chunsheng
• Is Part Of: Advanced science. Volume 6:Issue 20(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-10-16
• Subjects: collateral effect -- CRISPR‐Cas13a -- EGFRvIII -- glioblastoma (GBM); Science -- Periodicals; 505
• DOI: 10.1002/advs.201970124
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : In article number1901299, Chunsheng Kang and co‐workers demonstrate the collateral effect of the CRISPR‐Cas13a system in glioma cells. EGFRvIII is a unique EGFR mutant subtype in glioma, and the CRISPR‐Cas13a system induces death in EGFRvIII‐overexpressing glioma cells. Furthermore, CRISPR‐Cas13a inhibits the formation of glioma intracranial tumors in mice. The results indicate the powerful tumor eliminating potential of this system.