Molecular design opportunities presented by solvent‐exposed regions of target proteins. Issue 6 (19th April 2019)

• Record Type: Journal Article
• Authors: Jiang, Xiangyi; Yu, Ji; Zhou, Zhongxia; Kongsted, Jacob; Song, Yuning; Pannecouque, Christophe; De Clercq, Erik; Kang, Dongwei; Poongavanam, Vasanthanathan; Liu, Xinyong; Zhan, Peng
• Is Part Of: Medicinal research reviews. Volume 39:Issue 6(2019)
• Page Start: 2194
• Page End: 2238
• Publication Date: 2019-04-19
• Subjects: drug design -- medicinal chemistry -- protein/solvent interface -- solvent‐accessible region -- solvent‐exposed region -- solvent‐filled pocket; Pharmacology -- Periodicals; Drugs -- Research -- Periodicals; 615
• DOI: 10.1002/med.21581
• Languages: English
• ISSNs: 0198-6325

Abstract

Abstract: Solvent‐exposed regions, or solvent‐filled pockets, within or adjacent to the ligand‐binding sites of drug‐target proteins provide opportunities for substantial modifications of existing small‐molecular drug molecules without serious loss of activity. In this review, we present recent selected examples of exploitation of solvent‐exposed regions of proteins in drug design and development from the recent medicinal‐chemistry literature. Abstract : The solvent‐exposed regions of target proteins provided great opportunities to molecular design.