Tandem repeated irritation test (TRIT) studies and clinical relevance: Post 2006. (2nd October 2019)

• Record Type: Journal Article
• Authors: Reddy, Rasika; Maibach, Howard
• Is Part Of: Cutaneous and ocular toxicology. Volume 38:Number 4(2019)
• Page Start: 309
• Page End: 314
• Publication Date: 2019-10-02
• Subjects: Tandem irritation -- combined exposures -- irritant contact dermatitis -- sodium lauryl sulfate -- tandem repeated irritation test; Dermatotoxicology -- Periodicals; Ocular toxicology -- Periodicals; Ocular pharmacology -- Periodicals; Dermatopharmacology -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1080/15569527.2018.1486853
• Languages: English
• ISSNs: 1556-9527

Abstract

Abstract: Background/Aims: Single or multiple applications of irritants can lead to occupational contact dermatitis, and most commonly irritant contact dermatitis (ICD). Tandem irritation, the sequential application of two irritants to a target skin area, has been studied using the Tandem Repeated Irritation Test (TRIT) to provide a more accurate representation of skin irritation. Objective: Here we present an update to Kartono's review on tandem irritation studies since 2006. Methods: We surveyed the literature available on PubMed, Embase, Google Scholar, and the UCSF Dermatology library databases since 2006. Results and discussion: The studies included discuss the tandem effects of common chemical irritants, organic solvents, occlusion as well as clinical relevance – and enlarge our ability to discern whether multiple chemical exposures are more or less likely to enhance irritation.