Social modulation of drug use and drug addiction. (15th November 2019)

• Record Type: Journal Article
• Authors: Pelloux, Yann; Giorla, Elodie; Montanari, Christian; Baunez, Christelle
• Is Part Of: Neuropharmacology. Volume 159(2019)
• Publication Date: 2019-11-15
• Subjects: Peer presence -- Animal models -- Cocaine -- Opiate -- Drug selfadministration -- Conditioned place preference; Neuropsychopharmacology -- Periodicals; Autonomic Agents -- Periodicals; Neuropsychopharmacologie -- Périodiques; Neuropsychopharmacology; Periodicals; Electronic journals; 615.78
• DOI: 10.1016/j.neuropharm.2019.02.027
• Languages: English
• ISSNs: 0028-3908

Abstract

Abstract: This review aims to demonstrate how social science and behavioral neurosciences have highlighted the influence of social interactions on drug use in animal models. In neurosciences, the effect of global social context that are distal from drug use has been widely studied. For human and other social animals such as monkeys and rodents, positive social interactions are rewarding, can overcome drug reward and, in all, protect from drug use. In contrast, as other types of stress, negative social experiences facilitate the development and maintenance of drug abuse. However, interest recently emerged in the effect of so-called "proximal" social factors, that is, social interactions during drug-taking. These recent studies have characterized the role of the drug considered, the sharing of drug experience and the familiarity of the peer which interaction are made with. We also examine the few studies regarding the sensorial mediator of social behaviors and critically review the neural mediation of social factors on drug use. However, despite considerable characterization of the factors modulating distal influences, the mechanisms for proximal influences on drug use remain largely unknown. This article is part of the Special Issue entitled 'The neuropharmacology of social behavior: from bench to bedside'. Highlights: - The influence of distal social factors (not present at the time of consumption) on drug use - The influence of proximal social factors (those present at the time of drug consumption) on drug use - What could be the neurobiological substrate for these influences by the social context