Global brain inflammation in stroke. Issue 11 (November 2019)

• Record Type: Journal Article
• Authors: Shi, Kaibin; Tian, De-Cai; Li, Zhi-Guo; Ducruet, Andrew F; Lawton, Michael T; Shi, Fu-Dong
• Is Part Of: Lancet neurology. Volume 18:Issue 11(2019)
• Page Start: 1058
• Page End: 1066
• Publication Date: 2019-11
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Nervous System Diseases -- Periodicals; Neurologie -- Périodiques; Neurology; Electronic journals; Periodicals; 616.805
• DOI: 10.1016/S1474-4422(19)30078-X
• Languages: English
• ISSNs: 1474-4422

Abstract

Summary: Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal cell death and the release of factors such as damage-associated molecular patterns (DAMPs) that elicit localised inflammation in the injured brain region. Such focal brain inflammation aggravates secondary brain injury by exacerbating blood–brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death. In addition to inflammation localised to the injured brain region, a growing body of evidence suggests that inflammatory responses after a stroke occur and persist throughout the entire brain. Global brain inflammation might continuously shape the evolving pathology after a stroke and affect the patients' long-term neurological outcome. Future efforts towards understanding the mechanisms governing the emergence of so-called global brain inflammation would facilitate modulation of this inflammation as a potential therapeutic strategy for stroke.