A Bio-molecular Sensor Based on Optical Weak Measurement. Issue 2 (August 2019)

• Record Type: Journal Article
• Authors: Xiong, Nian; Wang, Xiangnan; Shi, Lixuan; Xu, Yang; Guan, Tian; He, Yonghong
• Is Part Of: Journal of physics. Volume 1302:Issue 2(2019)
• Publication Date: 2019-08
• Subjects: Physics -- Congresses; 530.5
• DOI: 10.1088/1742-6596/1302/2/022057
• Languages: English
• ISSNs: 1742-6588

Abstract

Abstract: We developed a phase-sensitive sensor based on the optical weak measurement for label-free detection of biomolecular interaction. The weak value amplification system can be implemented in common-path with total internal reflection structure. The phase difference between p and s polarizations caused by biomolecular recognition is measured by the central wavelength shift of the frequency domain weak measurement system. Structure of p and s polarizations in common-path makes system robust and stable. The applicability is illustrated by real-time monitoring interaction of biomolecules.