The effects of Mn and/or Ni dopants on the in vitro/in vivo performance, structural and magnetic properties of β-tricalcium phosphate bioceramics. Issue 17 (1st December 2019)

• Record Type: Journal Article
• Authors: Ates, Tankut; Dorozhkin, Sergey V.; Kaygili, Omer; Kom, Mustafa; Ercan, Ismail; Bulut, Niyazi; Firdolas, Fatih; Keser, Serhat; Gursoy, N. Canan; Ozercan, Ibrahim H.; Eroksuz, Yesari; İnce, Turan
• Is Part Of: Ceramics international. Volume 45:Issue 17(2019)Part B
• Page Start: 22752
• Page End: 22758
• Publication Date: 2019-12-01
• Subjects: β-tricalcium phosphate -- Dopants -- Magnetic properties -- In vitro -- In vivo; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2019.07.314
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: The present study describes the effects of dopants of Mn and/or Ni on the structural, magnetic and in vivo/in vitro performances of β-tricalcium phosphate (β-TCP) bioceramics synthesized by a sol-gel method. Both types of dopants caused significant effects on the structure-related parameters of β-TCP, including the crystallite dimensions and lattice parameters. The magnetic properties of as-prepared samples were found to be affected by the type and amount of the dopant(s). The in vitro antimicrobial activities of doped β-TCPs against American Type Culture Collection (ATCC) reference bacterial and fungal strains were evaluated. Among them, only 1.35Ni-TCP displayed an effective antimicrobial activity against Gram-positive bacteria (50 μg/mL Minimum Inhibitory Concentration (MIC) range), while other types of doped β-TCPs did not possess with such effect. The in vivo tests showed that each formulation could be a good nominate for bone healing and bone treatment.