Role of immunological markers in gestational diabetes mellitus-a brief review. Issue 5 (September 2019)

• Record Type: Journal Article
• Authors: Siddiqui, Samreen; Waghdhare, Swati; Jha, Sujeet; Dubey, Shweta
• Is Part Of: Diabetes & metabolic syndrome. Volume 13:Issue 5(2019)
• Page Start: 2983
• Page End: 2985
• Publication Date: 2019-09
• Subjects: Gestational diabetes -- Cytokines -- Insulin resistance; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2018.07.018
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Gestational Diabetes Mellitus (GDM) is a condition which develops due to insulin resistance. There are a number of immunological markers (IL-6, TNF-α, IL-10, etc), which play significant role during normal pregnancy and their irregular levels could likely cause some level of insulin resistance. There are studies which have compared the levels of different immunological mediators in GDM affected females and their healthy controls, but their findings are little controversial. Some of the studies have reported increased levels of IL-6, TNF-α, adiponectin, leptin, in females affected with GDM, while others do not confirm this. We have tried to summarize, in this short review, the findings of research studies being conducted globally, which have reported the association of insulin resistance, GDM and immunological markers. Our review suggests that there is a need for high quality data on the immunological parameters associated with GDM, especially from India.