Protective effect of vanillic acid against benzo(a)pyrene induced lung cancer in Swiss albino mice. Issue 10 (30th August 2019)

• Record Type: Journal Article
• Authors: Velli, Sathesh kanna; Sundaram, Jagan; Murugan, Manikandan; Balaraman, Gopalakrishnan; Thiruvengadam, Devaki
• Is Part Of: Journal of biochemical and molecular toxicology. Volume 33:Issue 10(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-08-30
• Subjects: antioxidants -- benzo(a)pyrene -- lung cancer -- vanillic acid; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Toxicology -- Periodicals; 574
• DOI: 10.1002/jbt.22382
• Languages: English
• ISSNs: 1095-6670

Abstract

Abstract: Vanillic acid (VA) is found in high concentrations in various plants and used as traditional medicine for various diseases. The aim of the existing study is to illustrate the protective effects of VA against benzo(a)pyrene (B(a)P)‐induced lung cancer in Swiss albino mice. B(a)P (50 mg/kg b.wt.) was given orally to induce lung cancer in mice. The body weight, tumor incidence, carcinoembryonic antigen (CEA), neuron‐specific enolase (NSE), and enzymatic/nonenzymatic antioxidants (superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and glutathione) were estimated. Further histochemical investigation through hematoxylin and eosin staining was also carried out. B(a)P administered groups showed increased levels of serum pathological markers CEA, NSE along with reduced final body weight as well as decreased tissue enzymatic and nonenzymatic antioxidants activities, whereas VA treatment (200mg/kg/b.wt) along with B(a)P showed significantly reverted the above changes, which proves as prominent anticancer effects in experimentally induced lung cancer. Overall, these results suggest that VA has an efficient preventive action against B(a)P‐induced lung cancer, and this is attributed to its free‐radical scavenging antioxidant activities. Abstract : Schematic represents the possible mechanism action of VA against B(a)P induced lung carcinogenesis. B(a)P administration increased the reactive oxygen species that leads to decreased enzymic and non‐enzymic antioxidants activities which ended up with increased tumor incidence and markers. VA treatment during B(a)P administration potentially attenuated the lung carcinogenesis through enhanced antioxidant activities thereby it reduced free radical generations.