Enantioselective hydrogenation of α‐ketoesters catalyzed by cinchona alkaloid stabilized Rh nanoparticles in ionic liquid. Issue 10 (16th July 2019)

• Record Type: Journal Article
• Authors: Jiang, He‐yan; Xu, Jie; Sun, Bin
• Is Part Of: Chirality. Volume 31:Issue 10(2019)
• Page Start: 818
• Page End: 823
• Publication Date: 2019-07-16
• Subjects: cinchona alkaloid -- enantioselective hydrogenation -- ionic liquid -- rhodium -- α‐ketoester; Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.23107
• Languages: English
• ISSNs: 0899-0042

Abstract

Abstract: The heterogeneous enantioselective hydrogenation of α‐ketoesters catalyzed by rhodium nanoparticles (Rh NPs) in ionic liquid was studied with the stabilization and modification of cinchona alkaloids. TEM characterization showed that well‐dispersed Rh NPs of about 1.96 nm were obtained in ionic liquid. The results showed that cinchona alkaloids not only had good enantiodifferentiating ability but also accelerated the catalytic reaction. Under the optimum reaction conditions, the enantiomeric excess in ethyl benzoylformate hydrogenation could reach as high as 60.9%. Abstract : Ionic liquid‐stabilized metal nanoparticles have been tested as catalysts primarily in the hydrogenation of alkenes or arenes. Herein, heterogeneous enantioselective hydrogenation of α‐ketoesters catalyzed by Rh NPs in ionic liquid was studied with the stabilization and modification of cinchona alkaloids. The results showed that cinchona alkaloids not only had good enantiodifferentiating ability but also accelerated the catalytic reaction.