Ligand‐Free FeCl2‐Catalyzed α‐Alkylation of Ketones with Alcohols. Issue 10 (2nd September 2019)

• Record Type: Journal Article
• Authors: Ibrahim, Jessica Juweriah; Reddy, C. Bal; Zhang, Shaochun; Yang, Yong
• Is Part Of: Asian journal of organic chemistry. Volume 8:Issue 10(2019)
• Page Start: 1858
• Page End: 1861
• Publication Date: 2019-09-02
• Subjects: ɑ-alkylation -- hydrogen borrowing -- iron catalyst -- ketones -- alcohols; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201900438
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: In this study, we present a facile, cost‐effective and expedient hydrogen‐borrowing strategy to perform α‐alkylation of ketones with primary alcohols using FeCl2 as the catalyst. A set of both ketones and alcohols could be efficiently alkylated to produce their corresponding ketones in good to high yields. Abstract : A ligand‐free FeCl2‐ catalyzed ɑ‐alkylation reaction of ketones with alcohols has been developed. A broad set of substrates were successfully alkylated in good to excellent yields.