Aryl Hydrocarbon Receptor Mediates Cell Proliferation Enhanced by Benzo[a]pyrene in Human Lung Cancer 3D Spheroids. (14th September 2019)

• Record Type: Journal Article
• Authors: Jimma, Yoko; Jimma, Keiko; Yachi, Maako; Hakata, Shuko; Habano, Wataru; Ozawa, Shogo; Terashima, Jun
• Is Part Of: Cancer investigation. Volume 37:Number 8(2019)
• Page Start: 367
• Page End: 375
• Publication Date: 2019-09-14
• Subjects: Lung cancer -- aryl hydrocarbon receptor -- benzo[a]pyrene -- 3D spheroid -- cell proliferation; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2019.1655760
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: The aryl hydrocarbon receptor (AhR) is activated by the ligand, benzo[a]pyrene (B[a]P), a component of smoke that is implicated in lung carcinogenesis in humans. However, the role of B[a]P and AhR in lung cancer malignancy is not well known. In this study, we analyzed the effects of B[a]P and AhR in the 3 D spheroids of human lung cancer cells in vitro . In these spheroids, B[a]P and AhR enhanced cancer cell proliferation. These results suggest that the AhR-dependent effects of B[a]P on cell proliferation may contribute to the adverse effects of continuous smoking with respect to lung cancer malignancy.