Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction. (2nd October 2019)

• Record Type: Journal Article
• Authors: Hendrix, Manouk L. E.; Palm, Kirsten C. M.; Van Kuijk, Sander M. J.; Bekers, Otto; Spaanderman, Marc E. A.; Bons, Judith A. P.; Al-Nasiry, Salwan
• Is Part Of: Hypertension in pregnancy. Volume 38:Number 4(2019)
• Page Start: 268
• Page End: 277
• Publication Date: 2019-10-02
• Subjects: Early Pregnancy Complications -- Eclampsia -- HELLP -- High-Risk Pregnancy -- Pregnancy induced Hypertension -- Placenta -- Preeclampsia -- Fetal Growth Restriction; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2019.1668948
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Objective : To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods : Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results : sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p< 0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements. Conclusion : Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.