Effect of Doxorubicin on Squamous Cell Carcinoma of Skin: Assessment by MRI Relaxometry at 4.7T. (14th September 2019)

• Record Type: Journal Article
• Authors: Sharma, Ashok; Sharma, Uma; Jagannathan, N. R.; Ray, Ruma; Rajeswari, Moganty Raja
• Is Part Of: Cancer investigation. Volume 37:Number 8(2019)
• Page Start: 339
• Page End: 354
• Publication Date: 2019-09-14
• Subjects: Skin tumor -- MRI -- spin-lattice Relaxation Time (T1) -- spin-spin Relaxation Time (T2) -- doxorubicin -- benzo(a)pyrene and HMGA1 proteins; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2019.1651327
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Squamous cell carcinoma (SCC) of skin has no standard treatment regimen, resulting in recurrences/metastasis. Although, doxorubicin (Dox), an anthracycline antibiotic has demonstrated some degree of efficacy. Molecular imaging can help in assessment of treatment response and prognosis of SCCs. MRI data showed that spin-spin relaxation (T2) time was longer (138 ± 2 msec) in Dox treated Test-II and there is no significant difference in spin-lattice relaxation (T1) time with respective controls. These findings further corroborated with the histology, proliferation index, apoptotic index, and HMGA1 protein expression. Thus, MRI may be a useful tool for monitoring treatment response noninvasively for skin tumor prognosis.