Polyethylene glycol (PEG-400): An efficient one-pot green synthesis and anti-viral activity of novel α-diaminophosphonates. (2nd November 2019)

• Record Type: Journal Article
• Authors: Patnala, Harika; Abbo, Hanna S.; Potla, Krishna Murthy; Titinchi, Salam J. J.; Chinnam, Sampath
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 194:Number 11(2019)
• Page Start: 1035
• Page End: 1039
• Publication Date: 2019-11-02
• Subjects: Green synthesis -- α-diaminophosphonates -- anti-viral activity -- Kabachnik-Fields reaction; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2019.1597365
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: An efficient and eco-friendly protocol has been accomplished for a series of novel α -diaminophosphonates by a one-pot, three-component system via Kabachnik-Fields reaction of 4, 4′-methylenedianiline, a variety of aryl/heteroaryl aldehydes and diphenylphosphite employing polyethylene glycol (PEG-400) as a green solvent at 80 °C. All products were obtained in good to excellent yields (80–95%). The identity of the new synthesized compounds was confirmed by IR, 1 H, 13C, and 31P NMR, LC-MS and elemental analysis. In vivo anti-viral activity was evaluated against tobacco mosaic virus (TMV). Compounds4b, 4c, 4j and4k exhibited the highest anti-viral activities against tobacco mosaic virus (TMV) when compared with the standard drug ningnanmycin. Graphical Abstract: