Three new lignanamides from the root of Lycium chinense with anti-inflammatory activity. Issue 23 (2nd December 2019)

• Record Type: Journal Article
• Authors: Chen, Fang; Huang, Xiao-jun; Liang, Qiu-ping; Huang, Yuan-peng; Lan, Ting; Zhou, Guang-xiong
• Is Part Of: Natural product research. Volume 33:Issue 23(2019)
• Page Start: 3378
• Page End: 3382
• Publication Date: 2019-12-02
• Subjects: Lycium chinense -- lignanamide -- enantiomer -- ECD calculations -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1478830
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new lignanamides, that is, a new lignanamide (1 ), and a pair of enantiomers (2a and2b ) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root of Lycium chinense . The structures of these new compounds, including their absolute configuration, were established on the basis of HR-ESI-MS, NMR spectroscopic data and quantum chemical ECD calculations. Compound2a showed significant anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC50 value of 10.77 ± 2.14 μM, comparing to that of positive control quercetin (17.21 ± 0.50 μM). Abstract :