Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort. (September 2019)

• Record Type: Journal Article
• Authors: Adarmes, A.D.; Almeria, M.; Alonso Losada, G.; Alonso Cánovas, A.; Alonso-Frech, F.; Arribas, S.; Ascunde Vidondo, A.; Aquilar, M.; Ávila, M.A.; Bernardo Lambrich, N.; Bejr-Kasem, H.; Blázquez Estrada, M.; Botí, M.; Cabello González, C.; Cabo López, I.; Caballol, N.; Cámara Lorenzo, A.; Carrillo, F.; Catalán, M.J.; Clavero, P.; Cortina Fernández, A.; Crespo Cuevas, A.; de Fábregues-Boixar, O.; Díez-Fairen, M.; Erro, E.; Estelrich Peyret, E.; Fernández Guillán, N.; Gámez, P.; Gallego, M.; García Caldentey, J.; García Campos, C.; García Moreno, J.M.; Gastón, I.; Gómez Garre, M.P.; González Aloy, J.; González-Aramburu, I.; González Ardura, J.; González García, B.; González Palmás, M.J.; González Toledo, G.R.; Golpe Díaz, A.; Grau Solá, M.; Guardia, G.; Hernández-Vara, J.; Horta Barba, A.; Infante, J.; Jesús, S.; Kulisevsky, J.; Kurtis, M.; Labandeira, C.; Labrador, M.A.; Lacruz, F.; Lage Castro, M.; Legarda, I.; López Ariztegui, N.; López Díaz, L.M.; López Manzanares, L.; López Seoane, B.; Martí Andres, G.; Martí, M.J.; Martínez-Castrillo, J.C.; McAfee, D.; Meitín, M.T.; Menéndez González, M.; Méndez del Barrio, C.; Miranda Santiago, J.; Morales Casado, M.I.; Moreno Diéguez, A.; Nogueira, V.; Novo Amado, A.; Novo Ponte, S.; Ordás, C.; Pagonabarraga, J.; Pareés, I.; Pascual-Sedano, B.; Pastor, P.; Pérez Fuertes, A.; Pérez Noguera, R.; Planellas, Ll; Pol Fuster, J.; Prats, M.A.; Prieto Jurczynska, C.; Puente, V.; Redondo Rafales, N.; Rodríguez Méndez, L.; Roldán, F.; Ruíz De Arcos, M.; Ruíz Martínez, J.; Sánchez Alonso, P.; Sánchez-Carpintero, M.; Sánchez Díez, G.; Sánchez Rodríguez, A.; Santacruz, P.; Segundo Rodríguez, J.C.; Seijo, M.; Serarols, A.; Sierra Peña, M.; Tartari, J.P.; Vargas, L.; Vázquez Gómez, R.; Villanueva, C.; Vives, B.; Villar, M.D.; Santos García, D.; de Deus Fonticoba, T.; Suárez Castro, E.; Borrué, C.; Mata, M.; Solano Vila, B.; Cots Foraster, A.; Álvarez Sauco, M.; Rodríguez Pérez, A.B.; Vela, L.; Macías, Y.; Escalante, S.; Esteve, P.; Reverté Villarroya, S.; Cubo, E.; Casas, E.; Arnaiz, S.; Carrillo Padilla, F.; Pueyo Morlans, M.; Mir, P.; Martinez-Martin, P.;
• Is Part Of: Parkinsonism & related disorders. Volume 66(2019)
• Page Start: 151
• Page End: 157
• Publication Date: 2019-09
• Subjects: Gait -- Mood -- Motor fluctuations -- Non-motor symptoms -- Parkinson's disease -- Quality of life; ADLS Schwab & England Activities of Daily Living Scale -- BDI, Beck Depression Inventory-II -- EUROHIS-QOL8 European Health Interview Survey-Quality of Life 8 Item-Index -- FOG freezing of gait -- FOGQ freezing of gait Questionnaire -- GQoL Global quality of life -- HRQoL health-related quality of life -- H&Y Hoenh & Yahr -- NMS non-motor symptoms -- NMSS Non-Motor Symptoms Scale -- NPI Neuropsychiatric Inventory -- PD Parkinson's disease -- PD-CRS Parkinson's Disease Cognitive Rating Scale -- PDQ-39SI 39-item Parkinson's Disease Quality of Life Questionnaire Summary Index -- PDSS Parkinson's Disease Sleep Scale -- QoL Quality of life -- QUIP-RS Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale -- UPDRS Unified Parkinson's Disease Rating Scale -- VAFS Visual Analog Fatigue Scale -- VAS-Pain Visual Analog Scale-Pain; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2019.07.031
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Objective: To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group. Methods: The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures. Results: QoL was worse in PD patients (n = 692; 62.6 ± 8.9 years old, 60.3% males) than controls (n = 206; 61 ± 8.3 years old, 49.5% males): PDQ-39, 17.1 ± 13.5 vs 4.4 ± 6.3 (p < 0.0001); PQ-10, 7.3 ± 1.6 vs 8.1 ± 1.2 (p < 0.0001); EUROHIS-QOL8, 3.8 ± 0.6 vs 4.2 ± 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (β = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, β = -0.46 and −0.21, respectively; EUROHIS-QOL8, β = -0.44 and −0.23, respectively). Conclusions: QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients. Highlights: Non-motor symptoms (NMS) are frequent in Parkinson's disease (PD) patients during the first steps of the disease. Health-related and global perceived quality of life (QoL) are worse in PD patients than controls. Strong correlation was observed between PQ-10 and EUROHIS-QOL8, both scales to provide global QoL. NMS burden, mood, and gait problems are the most significant factors contributing to a worse QoL. In practice, it is necessary to ask about NMS, mood, and gait problems in PD patients during their first years of evolution.