Oocyte donation in donors with levonorgestrel intrauterine device: a good match?. Issue 4 (October 2019)

• Record Type: Journal Article
• Authors: Galvão, Ana; Karakus, Gunes; Racca, Annalisa; Santos-Ribeiro, Samuel; De Munck, Neelke; Drakopoulos, Panagiotis; De Vos, Michel; Verheyen, Greta; Tournaye, Herman; Blockeel, Christophe
• Is Part Of: Reproductive biomedicine online. Volume 39:Issue 4(2019)
• Page Start: 641
• Page End: 647
• Publication Date: 2019-10
• Subjects: Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2019.05.022
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: Research question: Does the levonorgestrel-releasing intrauterine device (LNG-IUD) influence cumulative live birth rate (CLBR) in oocyte donor cycles? Design: Retrospective cohort study based on prospectively collected data from 1 May 2009 to 31 December 2017, without attrition, consisting of 491 consecutive cycles of vitrified oocyte donation, none lost to follow-up (unique donor–recipient pairs). All donors underwent ovarian stimulation using gonadotrophin releasing hormone (GnRH) antagonist co-treatment and GnRH agonist trigger. CLBR was chosen as primary outcome measure. Results: In total, 103 (21.0%) cycles were carried out in donors carrying a LNG-IUD. In 388 (79.0%) cycles, no LNG-IUD was present. After confounder-adjustment, the use of an LNG-IUD did not have a statistically significant influence on CLBR. Conclusions: The LNG-IUD does not negatively affect CLBR.