Profile of a Novel Anionic Fluoroquinolone—Delafloxacin. (8th April 2019)

• Record Type: Journal Article
• Authors: Tulkens, Paul M; Van Bambeke, Françoise; Zinner, Stephen H
• Is Part Of: Clinical infectious diseases. Volume 68(2019)Supplement 3
• Page Start: S213
• Page End: S222
• Publication Date: 2019-04-08
• Subjects: fluoroquinolones -- delafloxacin -- skin infections; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciy1079
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Fluoroquinolones have been in clinical use for over 50 years with significant efficacy. However, increasing resistance and emergence of some marked adverse events have limited their usage. The most recently approved class member, delafloxacin, is the only available anionic (non-zwitterionic) fluoroquinolone. Its unique molecular structure provides improved in vitro activity against most Gram-positive pathogens, including quinolone-resistant strains, which is further enhanced at acid pH. Delafloxacin shows favorable pharmacological properties, with about 60% bioavailability after oral administration, only mild inhibition of cytochrome P450 3A, and no evidence of cardiac- or phototoxicity in healthy volunteers (tested against positive controls). Its twice daily dosing, suitability for intravenous, oral, or switch dosing, the lack of many clinically significant drug-drug interactions, and acceptable adverse event profile in registration clinical trials supports its use in the treatment of acute bacterial skin and skin structure infections, and potentially in other infections, where resistance to other agents, safety, and/or the need for early discharge is of concern.