Emerging antimicrobial resistance causing therapeutic failure in neonatal sepsis. (July 2019)

• Record Type: Journal Article
• Authors: Khaliq, Abdul; Rahman, Saeed Ur; Gul, Saleha; ur-Rehman, Zaka-; Khan, Mahtab Ahmad; Shaheryar, Zaib Ali; Zaman, Muhammad; Zaidi, Awais Ali
• Is Part Of: Biocatalysis and agricultural biotechnology. Number 20(2019)
• Publication Date: 2019-07
• Subjects: Antibiotics -- Empirical therapy -- Neonatal sepsis -- Microbial resistance; Agricultural biotechnology -- Periodicals; Enzymes -- Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.bcab.2019.101233
• Languages: English
• ISSNs: 1878-8181

Abstract

Abstract: Neonatal sepsis maintains its rank as being one of the principal causes of neonatal morbidity as well as mortality in the developing countries. Treatment outcomes associated with neonatal sepsis continue to change with time and space. These varying trends fundamentally influenced by the resistance being emerged in neonatal pathogens which cause sepsis. This study focused on the comprehension kaleidoscopic trends of bacterial resistance in neonatal pathogens which in turn are manifesting in the form of failure of empirical antimicrobial treatment for sepsis in neonates. Our results showed that bacterial pathogens isolated found to be causing sepsis in neonates include; Klebsiella spp, Methicillin-resistant Staphylococcus aureus (M.R.S.A), Pseudomonas aeruginosa, Staphylococcus spp, Neisseria meningitides, Streptococcus spp and E.Coli. The most resistant of theses microbial isolates came out to be Klebsiella spp and Pseudomonas aeruginosa. In the current study the positive outcomes are signified by the improvements in pathological parameters as well as biochemical and physical signs and symptoms. The negative outcomes, on the other hand, are represented by deteriorating or absence of any improvement of the signs and symptoms neonates. Overall, the negative outcomes were found fifty two percent, whereas the positive outcomes were recorded as forty eight percent. This underscores the alarming trend of therapeutic failures due to emerging antimicrobial resistance in neonatal being emerged in population. Highlights: Neonatal sepsis remains one of the challenging problem in developing countries. Treatment outcomes associated with neonatal sepsis change with time and space. The positive outcomes are based on the improvements in signs and symptoms. Eight different pathogens were isolated and subsequently identified. Treatment failure was played by antimicrobial resistance in neonatal pathogens causing sepsis.