Correlation between tcdB gene PCR cycle threshold and severe Clostridium difficile disease. (October 2019)

• Record Type: Journal Article
• Authors: De Francesco, M.A.; Lorenzin, G.; Piccinelli, G.; Corbellini, S.; Bonfanti, C.; Caruso, A.
• Is Part Of: Anaerobe. Volume 59(2019)
• Page Start: 141
• Page End: 144
• Publication Date: 2019-10
• Subjects: PCR -- Cycle threshold -- Leukocytosis; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2019.06.017
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: A retrospective study, including all samples tested for Clostridium difficile from 2015 to 2018, was conducted. 222 and 199 patients were respectively classified as having a mild/moderate or severe disease. A CT ≤ 26 was significantly associated with severe disease. Furthermore, low CT values were significantly associated to older patients and leukocytosis. Highlights: Colonization rate with Clostridium difficile is high. A CT ≤ 26 was significantly associated with severe disease. A CT ≤ 26 was associated to older patients and to leukocytosis.