Safety issues related to the electronic cross-matching of blood in mainland China: A prospective cohort study involving cross-matching of 40, 228 blood samples. Issue 35 (August 2019)

• Record Type: Journal Article
• Authors: Wang, Yuan-Jie; Liu, Jia-Rui; Liu, Yong
• Other Names: Eskazan. Ahmet Emre section editor.
• Is Part Of: Medicine. Volume 98:Issue 35(2019)
• Publication Date: 2019-08
• Subjects: antibody screening -- antigenic spectrum -- electronic cross-matching -- undetected antibody; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000016703
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Although the electronic cross-matching of blood has been widely applied in some developed countries and regions, concern over the risk of undetected red blood cell (RBC) antibodies has limited its application in mainland China. This study was performed to explore the missed detection rate of RBC antibodies in a Chinese population from 2011 to 2016. If the results of 2 consecutive tests of ABO/RhD blood group identification were consistent and antibody screening results were negative, electronic cross-matching of the blood was performed. In addition, traditional serological cross-matching of blood (polybrene method) and a parallel experiment for electronic cross-matching of blood were performed to analyze the missed detection of unexpected RBC antibodies in blood donors and recipients. Using the polybrene method, 40, 228 blood samples were tested by parallel traditional serological cross-matching of blood; among these samples, blood compatibility was found in 40, 222 cases, primary incompatibility (incompatibility of the donor's erythrocytes with the recipient's serum) was found in 6 cases, and no secondary incompatibility was found. Identification of antibody specificity was performed using panel cells, and all unexpected RBC antibodies were confirmed as anti-Mur alloantibodies in the MNS system. Further improvements in the erythrocyte antigenic spectrum, especially the Mur antigen in Asian populations, are expected to ensure the safety of implementing electronic cross-matching in China. Abstract : Supplemental Digital Content is available in the text