Energy‐Free, Singlet Oxygen‐Based Chemodynamic Therapy for Selective Tumor Treatment without Dark Toxicity. Issue 18 (31st July 2019)

• Record Type: Journal Article
• Authors: Chen, Yanrui; Deng, Jian; Liu, Fang; Dai, Peipei; An, Yang; Wang, Zheng; Zhao, Yanjun
• Is Part Of: Advanced healthcare materials. Volume 8:Issue 18(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-07-31
• Subjects: ascorbates -- chemodynamic therapy -- metal organic frameworks -- nanoparticles -- singlet oxygen; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201900366
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Traditional singlet oxygen‐based antitumor therapies have been burdened with the necessity of external energy (e.g., light and ultrasound) and harmful dark toxicity. Ascorbate at the pharmacological concentration could accumulate hydrogen peroxide only in the tumor site. It is postulated that the concurrent delivery of ascorbate and nanoparticulate hypochlorous ion (ClO − ) could produce singlet oxygen at the tumor site as an energy‐free, tumor‐specific therapy. The ClO − is loaded in a hybrid core–shell nanocarrier consisting of a zeolitic imidazolate framework and amphiphilic poloxamer 188. Intracellular singlet oxygen production is verified in 4T1 cells by the cooperation between hybrid nanocarriers and ascorbate, which induces significant apoptotic cell death. Upon intravenous nanocarriers delivery plus intraperitoneal ascorbate administration to xenograft mice, the in vivo antitumor efficacy of this cooperative nanomedicine is demonstrated without noticeable side‐effects. This work demonstrates a proof‐of‐concept of singlet oxygen‐based chemodynamic therapy for selective tumor eradication, which produces a novel trigger‐free, singlet oxygen‐based cancer therapy without the side effects of traditional photodynamic and sonodynamic therapy. Abstract : A singlet oxygen‐based chemodynamic therapy is developed for selective tumor treatment. This is achieved by the cooperation between nanoparticulate hypochlorous ion and hydrogen peroxide, which is produced by ascorbate and accumulates only in the tumor site. Such a strategy can avoid the use of external energy (e.g., light and ultrasound) and prevent the dark toxicity of traditional photodynamic therapy and sonodynamic therapy.