Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment‐free and overall survival in Chronic Lymphocytic Leukaemia. (21st February 2018)

• Record Type: Journal Article
• Authors: Crassini, Kyle R.; Zhang, Eva; Balendran, Shalini; Freeman, Jane A.; Best, O. Giles; Forsyth, Cecily J.; Mackinlay, Naomi J.; Han, Ping; Stevenson, William S.; Mulligan, Stephen P.
• Is Part Of: British journal of haematology. Volume 181:Number 1(2018)
• Page Start: 97
• Page End: 101
• Publication Date: 2018-02-21
• Subjects: chronic lymphocytic leukaemia -- immunoglobulin -- immunoglobulin G subclasses -- survival; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.15146
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease ( P < 0·001 and P < 0·001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment‐free survival (TFS) ( P < 0·001 and P = 0·006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.