A facile green approach for fabricating bacterial cellulose scaffold with macroporous structure and cell affinity. (November 2019)

• Record Type: Journal Article
• Authors: Zhong, Meiling; Li, Jinsheng; Tang, Aoqi; Zhang, Qi; Ji, Dehui; Peng, Mengxia; Zhang, Richao; Xiong, Guangyao; Wan, Yizao; Fan, Hongsong
• Is Part Of: Journal of bioactive and compatible polymers. Volume 34:Number 6(2019:Nov.)
• Page Start: 442
• Page End: 452
• Publication Date: 2019-11
• Subjects: Bacterial cellulose -- extracellular matrix -- macroporous structure -- cell affinity -- tissue engineering -- gelatin -- procyanidins crosslinking; Biomedical materials -- Periodicals; Polymers in medicine -- Periodicals; Polymers -- Periodicals; 547.7
• DOI: 10.1177/0883911519877432
• Languages: English
• ISSNs: 0883-9115

Abstract

Bacterial cellulose holds great promise for tissue engineering, but its application is greatly limited due to the lack of large pores and poor cell affinity. In this study, macroporous bacterial cellulose was fabricated through the dissolution of gelatin microspheres, which were incorporated with bacterial cellulose during bacterial cellulose fabrication. Then, gelatin was immobilized onto bacterial cellulose surface via procyanidins crosslinking. The results confirmed that the scaffolds possessed interconnected macroporous structure, high porosity, good water uptake ability, and good mechanical properties. The results of evaluation of cells showed that cells migrated to the inner of macroporous affinitive bacterial cellulose and displayed better spreading as well as proliferation than that on pure bacterial cellulose surfaces. The macroporous affinitive bacterial cellulose show potential as a scaffold for tissue engineering.