Keep talking: crosstalk between iron and sulfur networks fine-tunes growth and development to promote survival under iron limitation. (20th June 2019)

• Record Type: Journal Article
• Authors: Mendoza-Cózatl, David G; Gokul, Arun; Carelse, Mogamat F; Jobe, Timothy O; Long, Terri A; Keyster, Marshall
• Editors: Kopriva, Stanislav
• Is Part Of: Journal of experimental botany. Volume 70:Number 16(2019)
• Page Start: 4197
• Page End: 4210
• Publication Date: 2019-06-20
• Subjects: Dynamic cell economy -- iron sensing -- iron use efficiency -- nutrient crosstalk -- sulfur homeostasis; Botany -- Periodicals; Botany, Experimental -- Periodicals; Plant physiology -- Periodicals; 580
• DOI: 10.1093/jxb/erz290
• Languages: English
• ISSNs: 0022-0957

Abstract

Abstract : Iron and sulfide are core components of Fe–S clusters but also highly toxic; therefore, crosstalk between Fe and S networks is critical to prevent the accumulation of toxic intermediaries. Abstract: Plants are capable of synthesizing all the molecules necessary to complete their life cycle from minerals, water, and light. This plasticity, however, comes at a high energetic cost and therefore plants need to regulate their economy and allocate resources accordingly. Iron–sulfur (Fe–S) clusters are at the center of photosynthesis, respiration, amino acid, and DNA metabolism. Fe–S clusters are extraordinary catalysts, but their main components (Fe 2+ and S 2− ) are highly reactive and potentially toxic. To prevent toxicity, plants have evolved mechanisms to regulate the uptake, storage, and assimilation of Fe and S. Recent advances have been made in understanding the cellular economy of Fe and S metabolism individually, and growing evidence suggests that there is dynamic crosstalk between Fe and S networks. In this review, we summarize and discuss recent literature on Fe sensing, allocation, use efficiency, and, when pertinent, its relationship to S metabolism. Our future perspectives include a discussion about the open questions and challenges ahead and how the plant nutrition field can come together to approach these questions in a cohesive and more efficient way.