Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda. Issue 2 (16th February 2019)

• Record Type: Journal Article
• Authors: Ssebambulidde, Kenneth; Segawa, Ivan; Laker, Eva; Lamorde, Mohammed; Castelnouvo, Barbara; Nakasujja, Noeline; Calcagno, Andrea
• Is Part Of: Oxford medical case reports. Volume 2019:Issue 2(2019)
• Publication Date: 2019-02-16
• Subjects: Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1093/omcr/omy132
• Languages: English
• ISSNs: 2053-8855

Abstract

Abstract: Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens' optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape.