A256 GLOBAL INCIDENCE OF ACUTE PANCREATITIS THROUGH TIME: A SYSTEMATIC REVIEW. (15th March 2019)

• Record Type: Journal Article
• Authors: Iannuzzi, J; Leung, J; Quan, J; Underwood, F; King, J A; Windsor, J W; Kaplan, G G
• Is Part Of: Journal of the Canadian Association of Gastroenterology. Volume 2(2019)Supplement 2
• Page Start: 499
• Page End: 501
• Publication Date: 2019-03-15
• Subjects: Gastroenterology -- Periodicals; 616.33005
• DOI: 10.1093/jcag/gwz006.255
• Languages: English
• ISSNs: 2515-2084

Abstract

Abstract: Background: Acute pancreatitis (AP) is a globally significant disease. Aims: The purpose of this study is to perform a systematic review of population-based cohort studies that explore the changing global and temporal incidence of AP. Methods: We performed a systematic literature search of MEDLINE (1946 onward) and EMBASE (1974 onward) up to 2018, to identify population-based studies reporting the incidence of AP with at least five temporal values. Studies reporting the incidence of the first occurrence of AP were examined separately from studies reporting incidence of first and recurrent occurrence of AP. Two teams of authors independently assessed abstracts to identify applicable papers for full-text review and data extraction. Temporal incidence data were summarized in a choropleth map to illustrate global differences in the incidence of AP over time. Results: We identified 38 studies reporting the temporal incidence of AP (Table 1). The incidence of AP is increasing over time in most countries in North America (e.g., USA: 43.3 to 85.6 per 100, 000; 1985–2012), Europe (Norway: 5.5 to 15.9 per 100, 000; 1996–2006), and Oceania (New Zealand: 41.3 to 76.8 per 100, 000; 2006–2014). In contrast, the incidence of AP varied in Asia with increasing incidence in China (30.5 to 39.2 per 100, 000; 2009–2014) and stable incidence in Vietnam (36.2 to 34.3 per 100, 000; 2000–2009). Conclusions: This systematic review provides a comprehensive overview of the global incidence of AP over the last 60 years. The incidence of AP is increasing over time in most countries. However, the reason for rising incidence is likely multifactorial relating to the changing standards of diagnosis, geographic variation in risk factors for AP, and differences in the surveillance systems for AP. Nonetheless, the overall trend of increasing incidence of AP highlights the increasing burden of AP on global health systems. Funding Agencies: None