Jasmonate and auxin perception: how plants keep F-boxes in check. (6th June 2019)

• Record Type: Journal Article
• Authors: Williams, Clara; Fernández-Calvo, Patricia; Colinas, Maite; Pauwels, Laurens; Goossens, Alain
• Is Part Of: Journal of experimental botany. Volume 70:Number 13(2019)
• Page Start: 3401
• Page End: 3414
• Publication Date: 2019-06-06
• Subjects: Arabidopsis -- coronatine -- heat shock protein -- JA-Ile -- neddylation -- polyubiquitination -- post-translational modification -- small molecule binding -- ubiquitin–proteasome system -- ubiquitination; Botany -- Periodicals; Botany, Experimental -- Periodicals; Plant physiology -- Periodicals; 580
• DOI: 10.1093/jxb/erz272
• Languages: English
• ISSNs: 0022-0957

Abstract

Abstract : Increased knowledge about protein–protein interactions, post-translational modifications, and modifying ligands of plant receptor F-box proteins will enable uncoupling of phytohormone responses and a more precise coordination of vital plant processes. Abstract: Phytohormones regulate the plasticity of plant growth and development, and responses to biotic and abiotic stresses. Many hormone signal transduction cascades involve ubiquitination and subsequent degradation of proteins by the 26S proteasome. The conjugation of ubiquitin to a substrate is facilitated by the E1 activating, E2 conjugating, and the substrate-specifying E3 ligating enzymes. The most prevalent type of E3 ligase in plants is the Cullin–RING ligase (CRL)-type, with F-box proteins (FBPs) as the substrate recognition component. The activity of these SKP–Cullin–F-box (SCF) complexes needs to be tightly regulated in time and place. Here, we review the regulation of SCF function in plants on multiple levels, with a focus on the auxin and jasmonate SCF-type receptor complexes. We discuss in particular the relevance of protein–protein interactions and post-translational modifications as mechanisms to keep SCF functioning under control. Additionally, we highlight the unique property of SCF TIR1/AFB and SCF COI1 to recognize substrates by forming co-receptor complexes. Finally, we explore how engineered selective agonists can be used to study and uncouple the outcomes of the complex auxin and jasmonate signaling networks that are governed by these FBPs.