Determination of Aromatic Amines in Urine using Extraction and Chromatographic Analysis: A Minireview. (12th December 2019)

• Record Type: Journal Article
• Authors: Yih Hui, Boon; Mohamad Zain, Nur Nadhirah; Mohamad, Sharifah; Mohamed Fauzi, Hafizuddin; Alias, Yatimah; Chandrasekaram, Kumuthini; Rahim, Nurul Yani; Yahaya, Noorfatimah; Raoov, Muggundha
• Is Part Of: Analytical letters. Volume 52:Number 18(2019)
• Page Start: 2974
• Page End: 2992
• Publication Date: 2019-12-12
• Subjects: Aromatic amines -- extraction -- gas chromatography (GC) -- high-performance liquid chromatography (HPLC) -- human urine -- sample preparation -- tobacco smoke; Chemistry, Analytic -- Periodicals; Chemistry, Analytic -- Abstracts; 543
• DOI: 10.1080/00032719.2019.1636057
• Languages: English
• ISSNs: 0003-2719

Abstract

Abstract: Aromatic amines found in tobacco smoke are carcinogenic to humans. There are no doubts that they cause of cancers in the lungs, bladder, kidneys, pancreas, esophagus, larynx, pharynx, and oral cavities associated with public health. Therefore, monitoring, control, and awareness toward the smoking effects are important subjects to be conveyed. Thus, rapid, sensitive, simple and accurate analytical methods for the identification of aromatic amines and their metabolites are required to provide a clear and complete visualization for the occurrence of aromatic amines by investigating the urine of smokers and nonsmokers. This comprehensive review serves to give an overview of the previous and recent studies about the analytical trends for the determination of urinary aromatic amines. This review covers the sampling methodologies and sample preparation techniques such as solvent extraction, solid phase extraction, magnetic solid phase extraction, and solid phase microextraction couple with different separation methods including gas chromatography and liquid chromatography. To add more value to this review paper, the advantages, disadvantages, challenges, and the future prospects of these methods are discussed as well. This review is hopefully beneficial for researchers to access and monitor the level of potentially carcinogenic aromatic amines in human urine.