Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus. Issue 6 (3rd May 2019)

• Record Type: Journal Article
• Authors: Nakaminami, Hidemasa; Takadama, Shunsuke; Okita, Miki; Sasaki, Mari; Noguchi, Norihisa
• Is Part Of: Journal of medical microbiology. Volume 68:Issue 6(2019)
• Page Start: 957
• Page End: 960
• Publication Date: 2019-05-03
• Subjects: qacA/B-positive methicillin-resistant Staphylococcus aureus -- olanexidine -- fast-acting bactericidal activity; Medical microbiology -- Periodicals; 616.9041
• DOI: 10.1099/jmm.0.000979
• Languages: English
• ISSNs: 0022-2615

Abstract

Abstract : The qacA/B gene is one of the major determinants of resistance to antiseptics in methicillin-resistant Staphylococcus aureus (MRSA). Here, we compared the fast-acting bactericidal activity of skin antiseptics, including olanexidine gluconate (OLG), a new biguanide antiseptic agent introduced in Japan, against clinical qacA/B -positive MRSA strains by determination of minimum bactericidal concentration and time–kill assay. Our findings provide, for the first time, data indicating that the fast-acting bactericidal activity of OLG against qacA/B -positive MRSA is higher than that of chlorhexidine gluconate, even though both are biguanide antiseptics.