Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis. Issue 3 (20th March 2019)

• Record Type: Journal Article
• Authors: McNeil, Matthew B.; Chettiar, Somsundaram; Awasthi, Divya; Parish, Tanya
• Is Part Of: Access microbiology. Volume 1:Issue 3(2019)
• Publication Date: 2019-03-20
• Subjects: mycobacteria -- permeability -- tuberculosis -- rifampicin -- Mycobacterium tuberculosis; Microbiology -- Periodicals; 579
• DOI: 10.1099/acmi.0.000006
• Languages: English
• ISSNs: 2516-8290

Abstract

Abstract : There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.