Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer. (October 2019)

• Record Type: Journal Article
• Authors: Eling, Laura; Bouchet, Audrey; Nemoz, Christian; Djonov, Valentin; Balosso, Jacques; Laissue, Jean; Bräuer-Krisch, Elke; Adam, Jean Francois; Serduc, Raphael
• Is Part Of: Radiotherapy and oncology. Volume 139(2019)
• Page Start: 56
• Page End: 61
• Publication Date: 2019-10
• Subjects: Synchrotron Microbeam Radiation Therapy -- High dose rate -- Normal tissue sparing -- Brain tumours responses; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2019.06.030
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: MRT is a form of synchrotron generated X-ray radiosurgery dedicated to brain tumours. Normal tissue tolerates high X-ray dose thanks through lattice of microbeams. MRT operates at very high dose rate (kGy·s −1 ) and triggers FLASH effect in vivo . Abstract: This paper reviews the current state of the art of an emerging form of radiosurgery dedicated to brain tumour treatment and which operates at very high dose rate (kGy·s −1 ). Microbeam Radiation Therapy uses synchrotron-generated X-rays which triggered normal tissue sparing partially mediated by FLASH effect.