Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants. Issue 5 (October 2019)

• Record Type: Journal Article
• Authors: Torres-Luna, Cesar; Hu, Naiping; Tammareddy, Tejaswi; Domszy, Roman; Yang, Jeffrey; Wang, Nam Sun; Yang, Arthur
• Is Part Of: Contact lens & anterior eye. Volume 42:Issue 5(2019)
• Page Start: 546
• Page End: 552
• Publication Date: 2019-10
• Subjects: Drug delivery -- Vitamin E -- NSAID -- Cationic surfactant -- Contact lenses; Anterior segment (Eye) -- Periodicals; Contact lenses -- Periodicals; Segment antérieur (Œil) -- Périodiques; Lentilles de contact -- Périodiques; 617.752305
• DOI: 10.1016/j.clae.2019.04.011
• Languages: English
• ISSNs: 1367-0484

Abstract

Abstract: The purpose of this study is to extend drug release from ACUVUE Oasys® and ACUVUE TruEye® silicone hydrogel contact lenses by incorporation of vitamin E in conjunction with a cationic surfactant. In ACUVUE Oasys® and ACUVUE TruEye®, the release of ketorolac tromethamine and flurbiprofen sodium is extended from hours to several days for 11% and 21% vitamin E, (weight of vitamin E / weight of dry lens) but with a considerable reduction in the amount of drug released. Cetalkonium chloride and stearylamine increased the drug loading capacity which was otherwise compromised by the addition of vitamin E in the contact lenses. In the case of diclofenac sodium, a sustained release over 150 h for both contact lenses can be achieved. It was found that the release-time-increase factor due to vitamin E has a linear dependence with the octanol-water partition coefficient of the drug in ACUVUE Oasys®. The results in this study show that contact lenses loaded with vitamin E in conjunction with cationic surfactants achieved sustained release of non-steroidal anti-inflammatory drugs (NSAIDs) within the therapeutic window.