From acylethynylpyrroles to pyrrole-pyrone ensembles in a one step. Issue 40 (3rd October 2019)

• Record Type: Journal Article
• Authors: Gotsko, Maxim D.; Saliy, Ivan V.; Sobenina, Lyubov' N.; Ushakov, Igor A.; Trofimov, Boris A.
• Is Part Of: Tetrahedron letters. Volume 60:Issue 40(2019)
• Publication Date: 2019-10-03
• Subjects: Acylethynylpyrroles -- Methylene active esters -- Nucleophilic addition -- Pyrrole-pyrones; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151126
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Previously unknown functionalized pyrrole-pyrone ensembles have been synthesized in up to 87%. [4+2]-Cyclization of available acylethynylpyrroles with methylene active esters. Yield of the target ensembles depended on the nature of the base. Abstract: Functionalized pyrrole-pyrone ensembles have been synthesized in up to 87% yields by KOH/MeCN [4+2]-cyclization of available acylethynylpyrroles with methylene active esters. The synthesized compounds, due to their potential rich chemistry, are rewarding building blocks for novel pyrrole-integrated complex molecules and promising precursors of medicine targeted compounds.