A novel benzopyran-based colorimetric and near-infrared fluorescent sensor for Hg2+ and its imaging in living cell and zebrafish. (January 2020)

• Record Type: Journal Article
• Authors: Lv, Hehong; Yuan, Gang; Zhang, Ganbing; Ren, Ziqi; He, Hanping; Sun, Qi; Zhang, Xiuhua; Wang, Shengfu
• Is Part Of: Dyes and pigments. Volume 172(2020)
• Publication Date: 2020-01
• Subjects: Hg2+ -- Near-infrared fluorescent probe -- Colorimetric -- High specificity -- Imaging of living cell and zebrafish; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2019.107658
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: A new near-infrared fluorescent probe (OTA-DCM), which contained a conjugated dicyanomethylene-benzopyran structure as the near-infrared fluorophore and dithia-dioxa-monoaza crown ether moiety as the receptor, was developed as a "naked-eye" indicator for Hg 2+ with rapid response, good binding constant (1.05 × 10 4 M −1 ), high selectivity and sensitivity. Moreover, OTA-DCM was successfully employed in real aqueous samples and fluorescent imaging for detection of Hg 2+ in living cells and zebrafish larvae with low cytotoxicity. Highlights: A new near-infrared fluorescent probe (OTA-DCM) was developed as a "naked-eye" indicator for Hg 2+ . The probe detected Hg 2+ with rapid response, good binding constant (1.05 × 10 4 M −1 ), high selectivity and sensitivity. The probe was employed in real aqueous samples and fluorescent imaging for detection of Hg 2+ in living cells and zebrafish larvae with low cytotoxicity.