Innate immune receptors for cross-presentation: The expanding role of NLRs. (September 2019)

• Record Type: Journal Article
• Authors: Corridoni, Daniele; Simmons, Alison
• Is Part Of: Molecular immunology. Volume 113(2019:Sep.)
• Page Start: 6
• Page End: 10
• Publication Date: 2019-09
• Subjects: PRRs -- NLRs -- Cross-presentation -- MHC class I -- CD8+ T cells; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2017.11.028
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: PRRs temporally control cross-presentation during acute vs. chronic pathogen handling. NLRs signal in close proximity to phagosomal and endosomal membranes. Current status of NLR-dependent regulation of MHC class antigen presentation. Abstract: A critical role of pattern recognition receptors (PRRs) is to influence adaptive immune responses by regulating antigen presentation. Engagement of PRRs in dendritic cells (DCs) increases MHC class I antigen presentation and CD8 + T-cell activation by cross-presented peptides but the molecular mechanisms underlying these effects are not completely understood. Studies looking at the role of PRRs in cross-presentation have been largely limited to TLRs but the role of other PRRs such as cytosolic nucleotide-binding oligomerization domain-like (NOD-like) receptors remains particularly enigmatic. Here we discuss recent evidence of the role of PRRs on cross-presentation and consider how cytosolic NLR-associated pathways, such as NOD2, may integrate these signals resulting in effective adaptive CD8 + T cells responses.